
S1RA hydrochloride
CAS No. 1265917-14-3
S1RA hydrochloride( E-52862 hydrochloride )
Catalog No. M11114 CAS No. 1265917-14-3
A potent and selective sigma-1 receptor antagonist with Ki of 17 nM; shows excellent selectivity over sigma-2 receptor (Ki>1 uM).
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
2MG | 49 | In Stock |
![]() ![]() |
5MG | 80 | In Stock |
![]() ![]() |
10MG | 120 | In Stock |
![]() ![]() |
25MG | 259 | In Stock |
![]() ![]() |
50MG | 405 | In Stock |
![]() ![]() |
100MG | 597 | In Stock |
![]() ![]() |
500MG | 1251 | In Stock |
![]() ![]() |
1G | Get Quote | In Stock |
![]() ![]() |
Biological Information
-
Product NameS1RA hydrochloride
-
NoteResearch use only, not for human use.
-
Brief DescriptionA potent and selective sigma-1 receptor antagonist with Ki of 17 nM; shows excellent selectivity over sigma-2 receptor (Ki>1 uM).
-
DescriptionA potent and selective sigma-1 receptor antagonist with Ki of 17 nM; shows excellent selectivity over sigma-2 receptor (Ki>1 uM); shows high activity in the mouse capsaicin model of neurogenic pain, exerts dose-dependent antinociceptive effects in several neuropathic pain models.Pain Phase 2 Clinical.
-
In Vitro——
-
In Vivo——
-
SynonymsE-52862 hydrochloride
-
PathwayAutophagy
-
TargetSigma receptor
-
Recptorσ2|σ1R
-
Research AreaNeurological Disease
-
IndicationPain
Chemical Information
-
CAS Number1265917-14-3
-
Formula Weight373.8765
-
Molecular FormulaC20H24ClN3O2
-
Purity>98% (HPLC)
-
SolubilityDMSO: ≥ 57 mg/mL
-
SMILESCC1=CC(=NN1C2=CC3=CC=CC=C3C=C2)OCCN4CCOCC4.Cl
-
Chemical NameMorpholine, 4-[2-[[5-methyl-1-(2-naphthalenyl)-1H-pyrazol-3-yl]oxy]ethyl]-, hydrochloride (1:1)
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference



-
AF-710B
AF-710B is a specific variant of M1 muscarinic and Sigma-1 receptor agonist used in the study of neurological disorders such as Alzheimer's disease dementia and schizophrenia.
-
PD 144418 oxalate
PD 144418 oxalate is a highly potent and selective sigma 1 (σ1) receptor ligand with a Ki value of 0.08 nM for σ1 and 1377 nM for σ2, exhibiting negligible affinity for other receptors, ion channels, and enzymes, and demonstrating potential antipsychotic activity.
-
KB-5492 free base
KB-5492 free base is an orally available and selective antiulcer agent that inhibits sigma receptors, inhibits [3H]1,3-di(2-tolyl)guanidine (DTG) binding to sigma receptors, and may be useful in the study of gastric lesions and gastric secretion.