S1RA hydrochloride

CAS No. 1265917-14-3

S1RA hydrochloride( E-52862 hydrochloride )

Catalog No. M11114 CAS No. 1265917-14-3

A potent and selective sigma-1 receptor antagonist with Ki of 17 nM; shows excellent selectivity over sigma-2 receptor (Ki>1 uM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 49 In Stock
5MG 80 In Stock
10MG 120 In Stock
25MG 259 In Stock
50MG 405 In Stock
100MG 597 In Stock
500MG 1251 In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    S1RA hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent and selective sigma-1 receptor antagonist with Ki of 17 nM; shows excellent selectivity over sigma-2 receptor (Ki>1 uM).
  • Description
    A potent and selective sigma-1 receptor antagonist with Ki of 17 nM; shows excellent selectivity over sigma-2 receptor (Ki>1 uM); shows high activity in the mouse capsaicin model of neurogenic pain, exerts dose-dependent antinociceptive effects in several neuropathic pain models.Pain Phase 2 Clinical.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    E-52862 hydrochloride
  • Pathway
    Autophagy
  • Target
    Sigma receptor
  • Recptor
    σ2|σ1R
  • Research Area
    Neurological Disease
  • Indication
    Pain

Chemical Information

  • CAS Number
    1265917-14-3
  • Formula Weight
    373.8765
  • Molecular Formula
    C20H24ClN3O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 57 mg/mL
  • SMILES
    CC1=CC(=NN1C2=CC3=CC=CC=C3C=C2)OCCN4CCOCC4.Cl
  • Chemical Name
    Morpholine, 4-[2-[[5-methyl-1-(2-naphthalenyl)-1H-pyrazol-3-yl]oxy]ethyl]-, hydrochloride (1:1)

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Díaz JL, et al. J Med Chem. 2012 Oct 11;55(19):8211-24. 2. Romero L, et al. Br J Pharmacol. 2012 Aug;166(8):2289-306. 3. Nieto FR, et al. J Pain. 2012 Nov;13(11):1107-21.
molnova catalog
related products
  • BMY-14802

    BMY-14802 (alpha-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazine butanol) is a selective and orally active sigma-1 antagonist with an IC50 of 112 nM.

  • 4-PPBP maleate

    4-PPBP maleate is a potent σ1 receptor (ligand) agonist and a selective, non-competitive NR1a/2B NMDA receptor antagonist in the context of Xenopus oocytes expression, with neuroprotective properties.

  • Sigma-1 receptor ant...

    Sigma-1 receptor antagonist 2 is a more potent and selective antagonist of sigma 1 receptor (σ1 R, Ki = 3.88 nM) than σ2 receptor (Ki = 1288 nM).